diff --git a/app/javascript/mastodon/features/emoji/index.ts b/app/javascript/mastodon/features/emoji/index.ts
index 4f23dc5395e..541cea9aa99 100644
--- a/app/javascript/mastodon/features/emoji/index.ts
+++ b/app/javascript/mastodon/features/emoji/index.ts
@@ -1,4 +1,5 @@
 import initialState from '@/mastodon/initial_state';
+import { loadWorker } from '@/mastodon/utils/workers';
 
 import { toSupportedLocale } from './locale';
 
@@ -9,9 +10,8 @@ let worker: Worker | null = null;
 export async function initializeEmoji() {
   if (!worker && 'Worker' in window) {
     try {
-      worker = new Worker(new URL('./worker', import.meta.url), {
+      worker = loadWorker(new URL('./worker', import.meta.url), {
         type: 'module',
-        credentials: 'omit',
       });
     } catch (err) {
       console.warn('Error creating web worker:', err);
diff --git a/app/javascript/mastodon/features/emoji/loader.ts b/app/javascript/mastodon/features/emoji/loader.ts
index 482d9e5c359..454b8383f07 100644
--- a/app/javascript/mastodon/features/emoji/loader.ts
+++ b/app/javascript/mastodon/features/emoji/loader.ts
@@ -36,15 +36,16 @@ async function fetchAndCheckEtag<ResultType extends object[]>(
 ): Promise<ResultType | null> {
   const locale = toSupportedLocaleOrCustom(localeOrCustom);
 
-  let uri: string;
+  // Use location.origin as this script may be loaded from a CDN domain.
+  const url = new URL(location.origin);
   if (locale === 'custom') {
-    uri = '/api/v1/custom_emojis';
+    url.pathname = '/api/v1/custom_emojis';
   } else {
-    uri = `/packs${isDevelopment() ? '-dev' : ''}/emoji/${locale}.json`;
+    url.pathname = `/packs${isDevelopment() ? '-dev' : ''}/emoji/${locale}.json`;
   }
 
   const oldEtag = await loadLatestEtag(locale);
-  const response = await fetch(uri, {
+  const response = await fetch(url, {
     headers: {
       'Content-Type': 'application/json',
       'If-None-Match': oldEtag ?? '', // Send the old ETag to check for modifications
diff --git a/app/javascript/mastodon/utils/workers.ts b/app/javascript/mastodon/utils/workers.ts
new file mode 100644
index 00000000000..02dd66d86e0
--- /dev/null
+++ b/app/javascript/mastodon/utils/workers.ts
@@ -0,0 +1,29 @@
+/**
+ * Loads Web Worker that is compatible with cross-origin scripts for CDNs.
+ *
+ * Returns null if the environment doesn't support web workers.
+ */
+export function loadWorker(url: string | URL, options: WorkerOptions = {}) {
+  if (!('Worker' in window)) {
+    return null;
+  }
+
+  try {
+    // Check if the script origin and the window origin are the same.
+    const scriptUrl = new URL(import.meta.url);
+    if (location.origin === scriptUrl.origin) {
+      // Not cross-origin, can just load normally.
+      return new Worker(url, options);
+    }
+  } catch (err) {
+    // In case the URL parsing fails.
+    console.warn('Error instantiating Worker:', err);
+  }
+
+  // Import the worker script from a same-origin Blob.
+  const contents = `import ${JSON.stringify(url)};`;
+  const blob = URL.createObjectURL(
+    new Blob([contents], { type: 'text/javascript' }),
+  );
+  return new Worker(blob, options);
+}
diff --git a/config/environments/development.rb b/config/environments/development.rb
index ca9e876e26b..79b491869cc 100644
--- a/config/environments/development.rb
+++ b/config/environments/development.rb
@@ -19,6 +19,9 @@ Rails.application.configure do
   # Enable server timing.
   config.server_timing = true
 
+  # Enable serving of images, stylesheets, and JavaScripts from an asset server.
+  config.asset_host = ENV['CDN_HOST'] if ENV['CDN_HOST'].present?
+
   # Enable/disable caching. By default caching is disabled.
   # Run rails dev:cache to toggle caching.
   if Rails.root.join('tmp', 'caching-dev.txt').exist?
diff --git a/vite.config.mts b/vite.config.mts
index 7f93157b7e1..f7871ece4d6 100644
--- a/vite.config.mts
+++ b/vite.config.mts
@@ -65,6 +65,11 @@ export const config: UserConfigFnPromise = async ({ mode, command }) => {
         // but it needs to be scoped to the whole domain
         'Service-Worker-Allowed': '/',
       },
+      hmr: {
+        // Forcing the protocol to be insecure helps if you are proxying your dev server with SSL,
+        // because Vite still tries to connect to localhost.
+        protocol: 'ws',
+      },
       port: 3036,
     },
     build: {