diff --git a/tests/fuzz/wasm-mutator-fuzz/CMakeLists.txt b/tests/fuzz/wasm-mutator-fuzz/CMakeLists.txt
index 8bb860788..60c6d92f2 100644
--- a/tests/fuzz/wasm-mutator-fuzz/CMakeLists.txt
+++ b/tests/fuzz/wasm-mutator-fuzz/CMakeLists.txt
@@ -90,8 +90,10 @@ add_compile_options(-Wno-unused-command-line-argument)
 
 # Enable fuzzer
 add_definitions(-DWASM_ENABLE_FUZZ_TEST=1)
-add_compile_options(-fsanitize=fuzzer)
-add_link_options(-fsanitize=fuzzer)
+# '-fsanitize=vptr' not allowed with '-fno-rtti
+# But, LLVM by default, disables the use of `rtti` in the compiler
+add_compile_options(-fsanitize=fuzzer -fno-sanitize=vptr)
+add_link_options(-fsanitize=fuzzer -fno-sanitize=vptr)
 
 # Enable sanitizers if not in oss-fuzz environment
 set(CFLAGS_ENV $ENV{CFLAGS})