diff --git a/CMakeLists.txt b/CMakeLists.txt
index c33b211e6..afa8af7d5 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -132,7 +132,7 @@ if (NOT WIN32)
 endif()
 
 if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
     set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
   endif ()
 endif ()
diff --git a/core/iwasm/libraries/wasi-nn/cmake/iwasm_helper.cmake b/core/iwasm/libraries/wasi-nn/cmake/iwasm_helper.cmake
index 670988e1d..0dc6e79fc 100644
--- a/core/iwasm/libraries/wasi-nn/cmake/iwasm_helper.cmake
+++ b/core/iwasm/libraries/wasi-nn/cmake/iwasm_helper.cmake
@@ -29,7 +29,7 @@ set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -Wall -Wextra -Wformat -Wformat-security -W
 set (CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -Wall -Wextra -Wformat -Wformat-security -Wno-unused")
 
 if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
     set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
   endif ()
 endif ()
diff --git a/product-mini/platforms/android/CMakeLists.txt b/product-mini/platforms/android/CMakeLists.txt
index 9cc8cc6b9..28bbad186 100644
--- a/product-mini/platforms/android/CMakeLists.txt
+++ b/product-mini/platforms/android/CMakeLists.txt
@@ -112,7 +112,7 @@ set_version_info (vmlib)
 set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,--gc-sections -pie -fPIE")
 
 if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
     set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
   endif ()
 endif ()
diff --git a/product-mini/platforms/cosmopolitan/CMakeLists.txt b/product-mini/platforms/cosmopolitan/CMakeLists.txt
index 37641497a..fcafcc3a2 100644
--- a/product-mini/platforms/cosmopolitan/CMakeLists.txt
+++ b/product-mini/platforms/cosmopolitan/CMakeLists.txt
@@ -137,7 +137,7 @@ set_version_info (vmlib)
 set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,--gc-sections")
 
 if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
     set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
     set (CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -mindirect-branch-register")
     # UNDEFINED BEHAVIOR, refer to https://en.cppreference.com/w/cpp/language/ub
diff --git a/product-mini/platforms/ios/CMakeLists.txt b/product-mini/platforms/ios/CMakeLists.txt
index bc8542ffe..2b71146cb 100644
--- a/product-mini/platforms/ios/CMakeLists.txt
+++ b/product-mini/platforms/ios/CMakeLists.txt
@@ -114,7 +114,7 @@ include (${WAMR_ROOT_DIR}/build-scripts/runtime_lib.cmake)
 set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,--gc-sections -pie -fPIE")
 
 if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
     set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
   endif ()
 endif ()
diff --git a/product-mini/platforms/linux/CMakeLists.txt b/product-mini/platforms/linux/CMakeLists.txt
index e369197dc..b6280aa6c 100644
--- a/product-mini/platforms/linux/CMakeLists.txt
+++ b/product-mini/platforms/linux/CMakeLists.txt
@@ -140,7 +140,7 @@ check_pie_supported()
 set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,--gc-sections")
 
 if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
     set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
     set (CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -mindirect-branch-register")
     # UNDEFINED BEHAVIOR, refer to https://en.cppreference.com/w/cpp/language/ub
diff --git a/samples/basic/CMakeLists.txt b/samples/basic/CMakeLists.txt
index e7417e634..e34961290 100644
--- a/samples/basic/CMakeLists.txt
+++ b/samples/basic/CMakeLists.txt
@@ -61,7 +61,7 @@ if (NOT MSVC)
     set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,--gc-sections")
   endif ()
   if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
       set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
     endif ()
   endif ()
diff --git a/samples/file/src/CMakeLists.txt b/samples/file/src/CMakeLists.txt
index d54e93c08..5efb55270 100644
--- a/samples/file/src/CMakeLists.txt
+++ b/samples/file/src/CMakeLists.txt
@@ -62,7 +62,7 @@ if (NOT MSVC)
     set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,--gc-sections")
   endif ()
   if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
       set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
     endif ()
   endif ()
diff --git a/samples/import-func-callback/CMakeLists.txt b/samples/import-func-callback/CMakeLists.txt
index be0cc5032..f1810880c 100644
--- a/samples/import-func-callback/CMakeLists.txt
+++ b/samples/import-func-callback/CMakeLists.txt
@@ -54,7 +54,7 @@ if (NOT MSVC)
   endif ()
   set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -Wall -Wextra -Wformat -Wformat-security")
   if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
       set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
     endif ()
   endif ()
diff --git a/samples/inst-context-threads/CMakeLists.txt b/samples/inst-context-threads/CMakeLists.txt
index b32d3053b..f6e373c69 100644
--- a/samples/inst-context-threads/CMakeLists.txt
+++ b/samples/inst-context-threads/CMakeLists.txt
@@ -62,7 +62,7 @@ if (NOT MSVC)
     set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,--gc-sections")
   endif ()
   if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
       set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
     endif ()
   endif ()
diff --git a/samples/inst-context/CMakeLists.txt b/samples/inst-context/CMakeLists.txt
index b9866a5eb..3152313d2 100644
--- a/samples/inst-context/CMakeLists.txt
+++ b/samples/inst-context/CMakeLists.txt
@@ -61,7 +61,7 @@ if (NOT MSVC)
     set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,--gc-sections")
   endif ()
   if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
       set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
     endif ()
   endif ()
diff --git a/samples/multi-module/CMakeLists.txt b/samples/multi-module/CMakeLists.txt
index 7d0499e4c..0e95d96ab 100644
--- a/samples/multi-module/CMakeLists.txt
+++ b/samples/multi-module/CMakeLists.txt
@@ -66,7 +66,7 @@ if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*
   set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,--gc-sections")
 endif ()
 if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
     set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
   endif ()
 endif ()
diff --git a/samples/native-stack-overflow/CMakeLists.txt b/samples/native-stack-overflow/CMakeLists.txt
index a2079bf4f..f86becea3 100644
--- a/samples/native-stack-overflow/CMakeLists.txt
+++ b/samples/native-stack-overflow/CMakeLists.txt
@@ -61,7 +61,7 @@ if (NOT MSVC)
     set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,--gc-sections")
   endif ()
   if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
       set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
     endif ()
   endif ()
diff --git a/samples/ref-types/CMakeLists.txt b/samples/ref-types/CMakeLists.txt
index 0d0852a2e..702e846ab 100644
--- a/samples/ref-types/CMakeLists.txt
+++ b/samples/ref-types/CMakeLists.txt
@@ -75,7 +75,7 @@ if (NOT MSVC)
     set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,--gc-sections")
   endif ()
   if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
       set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
     endif ()
   endif ()
diff --git a/samples/shared-heap/CMakeLists.txt b/samples/shared-heap/CMakeLists.txt
index 94690a4ed..6d41de0d7 100644
--- a/samples/shared-heap/CMakeLists.txt
+++ b/samples/shared-heap/CMakeLists.txt
@@ -62,7 +62,7 @@ if (NOT MSVC)
     set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,--gc-sections")
   endif ()
   if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
       set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
     endif ()
   endif ()
diff --git a/samples/shared-module/CMakeLists.txt b/samples/shared-module/CMakeLists.txt
index 4c9201e51..8bd3b2399 100644
--- a/samples/shared-module/CMakeLists.txt
+++ b/samples/shared-module/CMakeLists.txt
@@ -66,7 +66,7 @@ if (NOT MSVC)
     set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,--gc-sections")
   endif ()
   if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
       set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
     endif ()
   endif ()
diff --git a/samples/terminate/CMakeLists.txt b/samples/terminate/CMakeLists.txt
index 380733258..196ff5842 100644
--- a/samples/terminate/CMakeLists.txt
+++ b/samples/terminate/CMakeLists.txt
@@ -69,7 +69,7 @@ if (NOT MSVC)
     set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,--gc-sections")
   endif ()
   if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
       set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
     endif ()
   endif ()
diff --git a/samples/wasm-c-api/CMakeLists.txt b/samples/wasm-c-api/CMakeLists.txt
index 15eafaf4b..a186bf654 100644
--- a/samples/wasm-c-api/CMakeLists.txt
+++ b/samples/wasm-c-api/CMakeLists.txt
@@ -90,7 +90,7 @@ if (NOT MSVC)
     set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,--gc-sections")
   endif ()
   if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+    if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
       set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
     endif ()
   endif ()
diff --git a/test-tools/aot-analyzer/CMakeLists.txt b/test-tools/aot-analyzer/CMakeLists.txt
index 04d3b636c..062f9d2c3 100644
--- a/test-tools/aot-analyzer/CMakeLists.txt
+++ b/test-tools/aot-analyzer/CMakeLists.txt
@@ -62,7 +62,7 @@ if (NOT DEFINED WAMR_BIG_ENDIAN)
 endif ()
 
 if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
     set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
   endif ()
 endif ()
diff --git a/tests/standalone/test-invoke-native/CMakeLists.txt b/tests/standalone/test-invoke-native/CMakeLists.txt
index ce659ae42..4c32a77a8 100644
--- a/tests/standalone/test-invoke-native/CMakeLists.txt
+++ b/tests/standalone/test-invoke-native/CMakeLists.txt
@@ -104,7 +104,7 @@ if (NOT WAMR_BUILD_PLATFORM STREQUAL "darwin")
 endif ()
 
 if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
-  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
+  if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang" OR MSVC))
     set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
   endif ()
 endif ()