diff --git a/.github/workflows/nightly_run.yml b/.github/workflows/nightly_run.yml
index d6e5ebd2b..acdfae270 100644
--- a/.github/workflows/nightly_run.yml
+++ b/.github/workflows/nightly_run.yml
@@ -346,9 +346,6 @@ jobs:
           # fast jit doesn't support SIMD
           - make_options_run_mode: $FAST_JIT_BUILD_OPTIONS
             extra_options: "-DWAMR_BUILD_SIMD=0"
-          # multi-tier jit doesn't support SIMD
-          - make_options_run_mode: $MULTI_TIER_JIT_BUILD_OPTIONS
-            extra_options: "-DWAMR_BUILD_SIMD=0"
     steps:
       - name: Install dependencies
         run: |
@@ -392,10 +389,6 @@ jobs:
         include:
           - os: ubuntu-22.04
             llvm_cache_key: ${{ needs.build_llvm_libraries_on_ubuntu.outputs.cache_key }}
-        exclude:
-          - make_options: $MULTI_TIER_JIT_BUILD_OPTIONS
-            sanitizer: asan
-        include:
           # classic interp doesn't support SIMD
           - make_options: $CLASSIC_INTERP_BUILD_OPTIONS
             extra_options: "-DWAMR_BUILD_SIMD=0"
@@ -410,6 +403,9 @@ jobs:
             extra_options: "-DWAMR_BUILD_MULTI_MODULE=0"
           - make_options: $LLVM_EAGER_JIT_BUILD_OPTIONS
             extra_options: "-DWAMR_BUILD_MULTI_MODULE=0"
+        exclude:
+          - make_options: $MULTI_TIER_JIT_BUILD_OPTIONS
+            sanitizer: asan
 
     steps:
       - name: checkout