diff --git a/core/iwasm/aot/aot_runtime.c b/core/iwasm/aot/aot_runtime.c
index fa3212dfa..13651805d 100644
--- a/core/iwasm/aot/aot_runtime.c
+++ b/core/iwasm/aot/aot_runtime.c
@@ -3267,6 +3267,10 @@ aot_invoke_native(WASMExecEnv *exec_env, uint32 func_idx, uint32 argc,
     bool ret = false;
     bh_assert(func_idx < aot_module->import_func_count);
 
+#if __has_feature(memory_sanitizer)
+#include <sanitizer/msan_interface.h>
+    __msan_unpoison(argv, (sizeof(uint32) * argc));
+#endif
     import_func = aot_module->import_funcs + func_idx;
     if (import_func->call_conv_wasm_c_api)
         func_ptr =