diff --git a/CMakeLists.txt b/CMakeLists.txt
index 2582b4926..a2abac7ca 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -25,9 +25,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   elseif (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(SEND_ERROR "Unsupported build target platform!")
   endif ()
 endif ()
 
diff --git a/build-scripts/runtime_lib.cmake b/build-scripts/runtime_lib.cmake
index e7f7860cf..ff714b132 100644
--- a/build-scripts/runtime_lib.cmake
+++ b/build-scripts/runtime_lib.cmake
@@ -41,9 +41,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
     elseif (CMAKE_SIZEOF_VOID_P EQUAL 8)
         # Build as X86_64 by default in 64-bit platform
         set (WAMR_BUILD_TARGET "X86_64")
-    else ()
+    elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
         # Build as X86_32 by default in 32-bit platform
         set (WAMR_BUILD_TARGET "X86_32")
+    else ()
+        message(SEND_ERROR "Unsupported build target platform!")
     endif ()
 endif ()
 
diff --git a/product-mini/platforms/android/CMakeLists.txt b/product-mini/platforms/android/CMakeLists.txt
index c59f98c0d..b20011023 100644
--- a/product-mini/platforms/android/CMakeLists.txt
+++ b/product-mini/platforms/android/CMakeLists.txt
@@ -35,9 +35,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   if (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(SEND_ERROR "Unsupported build target platform!")
   endif ()
 endif ()
 
diff --git a/product-mini/platforms/darwin/CMakeLists.txt b/product-mini/platforms/darwin/CMakeLists.txt
index 6485b5903..588b5d166 100644
--- a/product-mini/platforms/darwin/CMakeLists.txt
+++ b/product-mini/platforms/darwin/CMakeLists.txt
@@ -22,9 +22,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   elseif (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(SEND_ERROR "Unsupported build target platform!")
   endif ()
 endif ()
 
diff --git a/product-mini/platforms/linux-sgx/CMakeLists.txt b/product-mini/platforms/linux-sgx/CMakeLists.txt
index 286d90596..6a06c061e 100644
--- a/product-mini/platforms/linux-sgx/CMakeLists.txt
+++ b/product-mini/platforms/linux-sgx/CMakeLists.txt
@@ -16,9 +16,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   if (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(SEND_ERROR "Unsupported build target platform!")
   endif ()
 endif ()
 
diff --git a/product-mini/platforms/linux-sgx/CMakeLists_minimal.txt b/product-mini/platforms/linux-sgx/CMakeLists_minimal.txt
index 336757401..9a33f8b47 100644
--- a/product-mini/platforms/linux-sgx/CMakeLists_minimal.txt
+++ b/product-mini/platforms/linux-sgx/CMakeLists_minimal.txt
@@ -16,9 +16,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   if (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(SEND_ERROR "Unsupported build target platform!")
   endif ()
 endif ()
 
diff --git a/product-mini/platforms/linux/CMakeLists.txt b/product-mini/platforms/linux/CMakeLists.txt
index c0b6f6a8c..542d27716 100644
--- a/product-mini/platforms/linux/CMakeLists.txt
+++ b/product-mini/platforms/linux/CMakeLists.txt
@@ -25,9 +25,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   elseif (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(SEND_ERROR "Unsupported build target platform!")
   endif ()
 endif ()
 
diff --git a/product-mini/platforms/vxworks/CMakeLists.txt b/product-mini/platforms/vxworks/CMakeLists.txt
index d681e9213..f15eb0594 100644
--- a/product-mini/platforms/vxworks/CMakeLists.txt
+++ b/product-mini/platforms/vxworks/CMakeLists.txt
@@ -24,9 +24,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   if (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(SEND_ERROR "Unsupported build target platform!")
   endif ()
 endif ()
 
diff --git a/product-mini/platforms/windows/CMakeLists.txt b/product-mini/platforms/windows/CMakeLists.txt
index bc82c8221..34f280fa5 100644
--- a/product-mini/platforms/windows/CMakeLists.txt
+++ b/product-mini/platforms/windows/CMakeLists.txt
@@ -23,9 +23,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   if (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(FATAL_ERROR "Unsupported build target platform!")
   endif ()
 endif ()
 
diff --git a/samples/basic/CMakeLists.txt b/samples/basic/CMakeLists.txt
index 7e10d4609..d408774da 100644
--- a/samples/basic/CMakeLists.txt
+++ b/samples/basic/CMakeLists.txt
@@ -33,9 +33,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   elseif (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(SEND_ERROR "Unsupported build target platform!")
   endif ()
 endif ()
 
diff --git a/samples/multi-module/CMakeLists.txt b/samples/multi-module/CMakeLists.txt
index e3edd0476..26c99d828 100644
--- a/samples/multi-module/CMakeLists.txt
+++ b/samples/multi-module/CMakeLists.txt
@@ -27,9 +27,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   elseif (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(SEND_ERROR "Unsupported build target platform!")
   endif ()
 endif ()
 
diff --git a/samples/multi-thread/CMakeLists.txt b/samples/multi-thread/CMakeLists.txt
index 89c983862..63c14eebd 100644
--- a/samples/multi-thread/CMakeLists.txt
+++ b/samples/multi-thread/CMakeLists.txt
@@ -27,9 +27,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   elseif (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(SEND_ERROR "Unsupported build target platform!")
   endif ()
 endif ()
 
diff --git a/samples/native-lib/CMakeLists.txt b/samples/native-lib/CMakeLists.txt
index 3968393c6..00eb40d94 100644
--- a/samples/native-lib/CMakeLists.txt
+++ b/samples/native-lib/CMakeLists.txt
@@ -27,9 +27,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   elseif (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(SEND_ERROR "Unsupported build target platform!")
   endif ()
 endif ()
 
diff --git a/samples/ref-types/CMakeLists.txt b/samples/ref-types/CMakeLists.txt
index 229afd3c4..3aac01d42 100644
--- a/samples/ref-types/CMakeLists.txt
+++ b/samples/ref-types/CMakeLists.txt
@@ -33,9 +33,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   elseif (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(SEND_ERROR "Unsupported build target platform!")
   endif ()
 endif ()
 
diff --git a/samples/socket-api/CMakeLists.txt b/samples/socket-api/CMakeLists.txt
index 936287c7d..5ce2543b9 100644
--- a/samples/socket-api/CMakeLists.txt
+++ b/samples/socket-api/CMakeLists.txt
@@ -125,9 +125,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   elseif (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(SEND_ERROR "Unsupported build target platform!")
   endif ()
 endif ()
 
diff --git a/samples/spawn-thread/CMakeLists.txt b/samples/spawn-thread/CMakeLists.txt
index 794ec2aa2..16618e303 100644
--- a/samples/spawn-thread/CMakeLists.txt
+++ b/samples/spawn-thread/CMakeLists.txt
@@ -27,9 +27,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   elseif (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(SEND_ERROR "Unsupported build target platform!")
   endif ()
 endif ()
 
diff --git a/samples/wasm-c-api/CMakeLists.txt b/samples/wasm-c-api/CMakeLists.txt
index c395b627a..38838e698 100644
--- a/samples/wasm-c-api/CMakeLists.txt
+++ b/samples/wasm-c-api/CMakeLists.txt
@@ -39,9 +39,11 @@ if (NOT DEFINED WAMR_BUILD_TARGET)
   elseif (CMAKE_SIZEOF_VOID_P EQUAL 8)
     # Build as X86_64 by default in 64-bit platform
     set (WAMR_BUILD_TARGET "X86_64")
-  else ()
+  elseif (CMAKE_SIZEOF_VOID_P EQUAL 4)
     # Build as X86_32 by default in 32-bit platform
     set (WAMR_BUILD_TARGET "X86_32")
+  else ()
+    message(SEND_ERROR "Unsupported build target platform!")
   endif ()
 endif ()